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USE OF BIBN4096 IN COMBINATION WITH OTHER ANTIMIGRAINE DRUGS FOR THE TREATMENT OF MIGRAINE

机译:将BIBN4096与其他抗胃炎药合用治疗偏头痛

摘要

The present invention relates to a method of treatment or prevention of headache, migraine or cluster headaches, which method comprises co-administration of a therapeutically effective amount of the compound A = 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1 H)-oxochinazolin-3-yl)-1-piperidinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096BS] or a physiologically acceptable salt thereof and a therapeutically effective amount of a second active antimigraine drug, particularly sumatriptan, zolmitriptan or dihydroergotamin or a physiologically acceptable salt thereof, as well as to the corresponding pharmaceutical compositions and the preparation thereof.
机译:本发明涉及治疗或预防头痛,偏头痛或丛集性头痛的方法,该方法包括共同给药治疗有效量的化合物A = 1- [N 2-[3,5-二溴- N-[[4-(3,4-二氢-2(1 H)-氧代中国唑啉-3-基)-1-哌啶基]-羰基] -D-酪氨酰] -L-赖氨酰] -4-(4-吡啶基-哌嗪[BIBN4096BS]或其生理上可接受的盐和治疗有效量的第二种活性抗偏头痛药物,特别是舒马曲坦,佐米曲坦或二氢麦角胺或其生理上可接受的盐,以及相应的药物组合物及其制备方法。

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