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PRENATAL DIAGNOSIS OF DOWN SYNDROME BY DETECTION OF FETAL RNA MARKERS IN MATERNAL BLOOD

机译:通过检测母体血液中的胎儿RNA标记进行唐氏综合症的产前诊断

摘要

The present invention relates to method for prenatal diagnosis of Down's syndrome-affected pregnancies. In the method fetal RNA, in particular placentally derived RNA indicative of Down's syndrome is detected in a maternal blood sample. Preferably in the method the placental RNA is detected in maternal blood plasma or serum obtained in the first trimester of pregnancy using RT-PCR for detection and preferably quantification of the RNA.
机译:本发明涉及唐氏综合症影响的妊娠的产前诊断方法。在该方法中,胎儿RNA,特别是在母体血液样品中检测到指示唐氏综合症的胎盘来源的RNA。优选地,在该方法中,使用RT-PCR在妊娠的前三个月的母体血浆或血清中检测胎盘RNA,以检测并优选定量RNA。

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