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NEW USE OF GAIN AND LOSS OF NOTCH2 FUNCTION IN BRAIN TUMORS AND THE NEW NOTCH2 GENETIC ALTERATIONS OF THE NOTCH2 GENE PER SE
NEW USE OF GAIN AND LOSS OF NOTCH2 FUNCTION IN BRAIN TUMORS AND THE NEW NOTCH2 GENETIC ALTERATIONS OF THE NOTCH2 GENE PER SE
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机译：脑肿瘤中增益和Notch2功能丧失的新用途以及每位Notch2基因的新Notch2基因改变
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摘要
The invention concerns the new use of gain and loss of Notch2 function by e.g. alterations of Notch2 in brain tumors, especially glioblastomas, astrocytomas and oligodendrogliomas and the new Notch2 genetic alteration of the Notch2 genes per se. In sum, it had been found that, while impaired Notch2 function is a key of oligodendrogliomas, gain of Notch2 function through overexpression is frequently observed in astrocytomas and glioblastomas. By these observations it had been learned that Notch2 may play a dual role in brain tumor development. All these results create opportunities for diagnostic test or new therapeutic useful.
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