首页> 外国专利> CLONING OF VERTEBRATE PHEROMONE RECEPTORS AND USES THEREOF

CLONING OF VERTEBRATE PHEROMONE RECEPTORS AND USES THEREOF

机译:脊椎动物信息素受体的克隆及其用途

摘要

This invention provides an isolated nucleic acid molecule encoding a vertebrate pheromone receptor. This invention also provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with a unique sequence within the sequence of the nucleic acid molecule which encodes a pheromone receptor. This invention provides a vector which comprises the above-described isolated nucleic acid molecule. This invention also provides a purified, vertebrate pheromone receptor. This invention provides an antibody capable of specifically binding to a vertebrate pheromone receptor. The invention further provides methods for identifying ligands capable of affecting the activity of a pheromone receptor. This invention provides different uses of the identified ligands. This invention also provides a transgenic nonhuman living organism expressing a pheromone receptor.
机译:本发明提供了编码脊椎动物信息素受体的分离的核酸分子。本发明还提供了至少12个核苷酸的核酸分子,其能够与编码信息素受体的核酸分子序列内的独特序列特异性杂交。本发明提供了包含上述分离的核酸分子的载体。本发明还提供了纯化的脊椎动物信息素受体。本发明提供了能够与脊椎动物信息素受体特异性结合的抗体。本发明进一步提供了鉴定能够影响信息素受体活性的配体的方法。本发明提供了所鉴定的配体的不同用途。本发明还提供表达信息素受体的转基因非人类活生物。

著录项

  • 公开/公告号EP0858505B1

    专利类型

  • 公开/公告日2004-12-29

    原文格式PDF

  • 申请/专利权人 UNIV COLUMBIA;

    申请/专利号EP19960936622

  • 发明设计人 DULAC CATHERINE;AXEL RICHARD;

    申请日1996-10-18

  • 分类号C12N15/00;

  • 国家 EP

  • 入库时间 2022-08-21 22:12:05

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