Methods of inhibiting mammalian platelet release of CD40 ligand, thromboxanes,or prostaglandin E2, or surface expression of CD40 ligand that involvecontacting mammalian platelets with an effective amount of a PPAR.gamma.agonist, an RXR agonist, or a combination thereof. As a consequence ofinhibiting CD40 ligand and thromboxane release, the present invention allowsfor inhibition of thrombus fon-nation by (or clotting activities of) activatedplatelets, as well as treating or preventing CD40 ligand-mediated conditionsand/or thromboxane-mediated conditions. Use of PPAR.gamma. agonist, RXRagonist, and/or inducers of PPAR.gamma. agonist in preparing a stored bloodproduct, and for diagnostic testing of patient samples is also disclosed.
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