The present invention relates to crystals of phosphorylated Aurora-A kinasefragment alone and in complex with a ligand, amino acid residues 1-43 of humanTPX2. This invention also relates to methods for designing and selectingligands, in particular allosteric inhibitors of Aurora-A, that bind to theAurora-A kinase and their use. Further, the present invention relates tocertain indene and indole derivatives.The present invention relates tocrystals of phosphorylated Aurora-A kinase alone and in complex with a ligand,amino acid residues 1-43 of human TPX2. This invention also relates to methodsfor designing and selecting ligands that bind to the Aurora-A kinase and theiruse. Further, the present invention relates to certain indene and indolederivative.
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