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CANCER IMMUNOTHERAPY USING ALLOSTIMULATED CELLS IN A MULTIPLE SEQUENTIAL IMPLANTATION STRATEGY

机译:在多种顺序植入策略中使用同种优化的细胞进行癌症免疫治疗

摘要

This invention provides medicaments and methods for managing cancer usingdonor cells that are alloactivated in culture. Alloactivatedcells are implanted into the bed of a solid tumor and initiate a response bythe host against the tumor. Subsequently, alloactivated cells areimplanted into the bed of a solid tumor a second time. The two implants worksynergistically to confer remarkable benefit to the treatedsubject, both in terms of management of the cancer and the development of ananti-cancer immune response. The beneficial effects mayinclude regression of the tumor and extended survival. Removal of any residualtumor after the second implant facilitates ongoing resistanceto tumor regrowth or metastasis.
机译:本发明提供了用于治疗癌症的药物和方法在培养中被同种异体激活的供体细胞。同素激活细胞被植入实体瘤床中并通过对抗肿瘤的宿主。随后,同种异体激活的细胞被第二次植入实体瘤床。两种植入物的工作协同作用,为治疗者带来明显的好处癌症的治疗和癌症的发展抗癌免疫反应。有益效果可能包括肿瘤消退和延长生存期。清除任何残留物第二次植入后的肿瘤促进了持续的抵抗肿瘤再生或转移。

著录项

  • 公开/公告号CA2346735C

    专利类型

  • 公开/公告日2005-01-25

    原文格式PDF

  • 申请/专利权人 MEYER PHARMACEUTICALS LLC;

    申请/专利号CA19982346735

  • 发明设计人 HISERODT JOHN C.;

    申请日1998-09-29

  • 分类号A61K35/14;C12N5/06;C12N5/08;

  • 国家 CA

  • 入库时间 2022-08-21 22:14:23

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