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ARILED AMIDAS OF FURANO- AND THIOPHEN-CARBOXYL ACIDS WITH A BLOCKING EFFECT OF THE POTASSIUM CHANNEL.
ARILED AMIDAS OF FURANO- AND THIOPHEN-CARBOXYL ACIDS WITH A BLOCKING EFFECT OF THE POTASSIUM CHANNEL.
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机译：呋喃和硫代羧酸的酰胺化反应，具有钾通道的阻滞作用。
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摘要
Compounds of ** formula ** in which they mean: X oxygen or sulfur; R (1) C (O) OR (9), SO2R (10), COR (11), C (O) NR (12) R (13) or C (S) NR (12) R (13); R (9), R (10), R (11) and R (12) independently of each other, CxH2x-R (14); x 0, 1, 2, 3 or 4, and x cannot be 0, when R (14) means OR (15) or SO2Me; R (14) alkyl with 1, 2, 3, 4, 5 or 6 C atoms, cycloalkyl with 3, 4, 5, 6, 7, 8, 9, 10 or 11 C atoms, CF3, C2F5, C3F7, CH2F, CHF2, OR (15), SO2Me, phenyl, naphthyl, biphenyl, furyl, thienyl, or a heteroaromatic radical containing N with 1, 2, 3, 4, 5, 6, 7, 8 or 9 C atoms, the phenyl, naphthyl, biphenyl, furyl, thienyl radicals and the heteroaromatic radical containing N being unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of F, CI, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1, 2, 3 or 4 C atoms, alkoxy with 1, 2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino.
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