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Erythropoietin composition with a multiple charged inorganic anion i.e. a sulfate a citrate or a phosphate to stabilize the composition
Erythropoietin composition with a multiple charged inorganic anion i.e. a sulfate a citrate or a phosphate to stabilize the composition
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机译：具有多电荷无机阴离子的促红细胞生成素组合物，即硫酸盐，柠檬酸盐或磷酸盐，以稳定组合物
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摘要
A liquid pharmaceutical composition comprising an erythropoietin protein, a multiple charged inorganic anion in a pharmaceutically acceptable buffer suitable to keep the solution pH in the range from about 5.5 to 7.0. The liquid composition is stable at room temperature for at least six months, is isotonic and may include one or more pharmaceutically acceptable excipients. This composition is especially useful for the prophylaxis and treatment of diseases related to erthropoiesis, having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells. The composition therefore can be used in medicaments to treat or prevent diseases correlated with anemia in chronic renal failure patients, AIDS and cancer patients undergoing chemotherapy.
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