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OB, the receptor for leptin, involved in body weight homeostasis nucleic acids encoding the receptor, and uses thereof e.g. identifing leptin analogues and therapeutically in gene therapy
OB, the receptor for leptin, involved in body weight homeostasis nucleic acids encoding the receptor, and uses thereof e.g. identifing leptin analogues and therapeutically in gene therapy
Described is the identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor is described. The receptor is expected to modulate leptin activity, in particular to agonise leptin activity. Further described are nucleic acids encoding the receptor, and methods for using the receptor, e.g., to identify leptin analogues, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity. (62) Divided out of 330972
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