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use of the pyrazoline derivatives in the preparation of a medicament for the prevention and / or treatment of diseases of the proliferation of the cells.
use of the pyrazoline derivatives in the preparation of a medicament for the prevention and / or treatment of diseases of the proliferation of the cells.
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机译：吡唑啉衍生物在制备用于预防和/或治疗细胞增殖性疾病的药物中的用途。
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摘要
The use of pyrazoline derivatives in the preparation of drugs for the prevention and / or treatment of cell proliferation diseases of pyrazoline derivativesWherein R1 is hydrogen, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, carboxylic acid, alkyl carboxylic acid with 1-4 carbon atoms, carboxamide or cyano group, R2 is hydrogen or methyl, R3, R4, R7 and R8, which are independent of hydrogen, chlorine, fluorine, methyl, trifluoromethyl or methoxy group, R5 and R6. Independently, they are hydrogen, chlorine, fluorine, methyl, trifluoromethyl, trifluoromethyl, methylsulfonyl, aminosulfonyl or acetylsulfonyl, provided that any of the R5 or R6 substituents is methylsulfonyl, aminosulfonyl or acetylaminosulfonyl, provided that R1 is methyl,Therefore, R2 is hydrogen or methyl, R3 and R8 are independent of hydrogen, chlorine, fluorine, methyl or trifluoromethyl, R4 is hydrogen, fluorine, methyl, trifluoromethyl or methyl, R5 is fluorine Methyl, trifluoromethyl, methoxy, trifluoromethyl, methylsulfonyl, sulfamoyl or acetylsulfamoyl, provided that R5 or R6 substituent is methylsulfonyl, sulfamoyl or acetylsulfamoyl, and R7 represents hydrogen atom, chlorine, fluorine, methyl, 1, 3. Trifluoromethyl or methoxy;The invention can be used for preventing or treating cell proliferation diseases.
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