首页> 外国专利> Salt isetionate mono - 6 - 8 - ciclopentil acetyl - 5 - methyl - 2 - (5 - piperazub - pyridin - il - 1 - 2 - ilamino) - 8h - 2.3 - dipirimidin Piro - 7 - one in their Crystalline forms,B and D; Preparation methods; Pharmaceutical Composition and its use for the treatment of cancer.

Salt isetionate mono - 6 - 8 - ciclopentil acetyl - 5 - methyl - 2 - (5 - piperazub - pyridin - il - 1 - 2 - ilamino) - 8h - 2.3 - dipirimidin Piro - 7 - one in their Crystalline forms,B and D; Preparation methods; Pharmaceutical Composition and its use for the treatment of cancer.

机译：异山梨醇盐单-6-8-乙酰环戊腈-5-甲基-2-（5-哌唑布-吡啶-il-1-2-氨基胺基）-8h-2.3-哌啶丁比罗[-7-一种结晶形式，B和D;制备方法;药物组合物及其在癌症治疗中的用途。

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摘要

Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.

机译：公开了6-乙酰基-8-环戊基-5-甲基-2-（5-哌嗪-1-基-吡啶-2-基氨基）-8H-吡啶并[2,3-d]嘧啶-的羟乙磺酸盐的多晶型物7-一，它是一种选择性的细胞周期蛋白依赖性激酶4（CDK4）抑制剂，可用于治疗炎症和细胞增生性疾病，例如癌症和再狭窄。

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公开/公告号CL2004001701A1

专利类型
公开/公告日2005-06-03

原文格式PDF
申请/专利权人 WARNER-LAMBERT COMPANY LLC;
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申请/专利号CL20040001701
发明设计人 VLADIMIR GENUKH BEYLIN;ANTHONY CLYDE BLACKBURN;DAVID THOMAS ERDMAN;PETER LAURENCE TOOGOOD;
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申请日2004-07-05
分类号A61K31/519;A61P17/06;A61P31/12;A61P35/00;A61P37/06;A61P9/10;C07D221/00;C07D239/00;C07D471/04;
国家 CL
入库时间 2022-08-21 22:18:20

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