首页> 外国专利> Procedure for obtaining a reaction product that comprises at least one Alkaloid Alkaloid derivative which has a Quaternary nitrogen; a reaction product Alkaloid derivative;Of quelidonina; and its use for the treatment of in

Procedure for obtaining a reaction product that comprises at least one Alkaloid Alkaloid derivative which has a Quaternary nitrogen; a reaction product Alkaloid derivative;Of quelidonina; and its use for the treatment of in

机译：获得包含至少一种具有季氮原子的生物碱生物碱衍生物的反应产物的方法;反应产物生物碱衍生物;槲皮素;及其在治疗中的用途

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摘要

The invention relates to alkaloid reaction products obtainable in a process wherein alkaloids are reacted with an alkylating agent, preferably thiotepa, whereafter unreacted alkylating agent and other water-soluble compounds are removed from the reaction mixture by washing with water or a suitable aqueous solvent, whereafter the reaction mixture is subjected to a treatment with strong acid, preferably hydrogen chloride (HCl), to precipitate a water soluble salt of the reaction products. The precipitated reaction products comprise at least one quaternary alkaloid derivative and are suitable as drugs for prophylactic or therapeutic application, particularly in the treatment of immunological or metabolic dysfunctions, and cancer. IMAGE

机译：本发明涉及生物碱反应产物，该生物碱反应产物可通过以下方法得到：生物碱与烷基化剂，优选噻替帕反应，然后通过用水或合适的水性溶剂洗涤从反应混合物中除去未反应的烷基化剂和其他水溶性化合物。反应混合物用强酸，优选氯化氢（HCl）处理，以沉淀反应产物的水溶性盐。沉淀的反应产物包含至少一种季生物碱衍生物，并且适合用作预防性或治疗性应用的药物，特别是用于治疗免疫学或代谢功能障碍和癌症的药物。 <图像>

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公开/公告号CL2004000552A1

专利类型
公开/公告日2005-01-21

原文格式PDF
申请/专利权人 WASSYL NOWICKY;
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申请/专利号CL20040000552
发明设计人 NOWICKY WASSYL;
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申请日2004-03-17
分类号A61K31/675;A61K35/78;A61P31/12;A61P35/00;C07D217/00;C07D317/00;C07D471/22;C07D491/02;C07D491/12;C07D491/22;C07F9/564;C07F9/59;C07F9/62;
国家 CL
入库时间 2022-08-21 22:18:22

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