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Immunogenic composition multivalent meningococcal Outer Membrane vesicles,,Which comprises a vesicle with a subserotipo homologous activity prevalent in a country and another vesicle with heterologous decreased activity, which has a P
Immunogenic composition multivalent meningococcal Outer Membrane vesicles,,Which comprises a vesicle with a subserotipo homologous activity prevalent in a country and another vesicle with heterologous decreased activity, which has a P
The present invention relates to vaccine compositions for the effective prevention of neisserial, preferably meningococcal, disease. The vaccine of the invention comprise a multivalent meningococcal bled composition comprising at least one bleb with homologous bactericidal activity which is derived from a meningococcal strain with a serosubtype that is prevalent in a country of use, and at least one bleb with heterologous bacterial activity which is derived from a meningococcal strain which need not have a serosubtype that is prevalent in the country of use.
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