Methods of reducing the possibility of mortality in an animal, virulent expression in an intestinal pathogen, and adhesin / lectin pa-i expression in a bacterial cell, inhibiting adhesin / lectin pa-i expression in an intestinal pathogen, intestine-induced activation of adhesin / lectin pa-i, c4-hsl-induced morphological change of an intestinal pathogen, and bacterial cell adhesion in a mammalian intestine, improvement of intestinal pathogenesis, disease prevention or abnormal condition, skin and respiratory infection, sexually transmitted disease, digestive tract disorder, loss of lactating capacity in an animal, and development of a microbe-mediated epithelial disorder in a nursing-age animal, irrigation of at least a portion of the urinary tract, and for monitoring the administration of poly (ethylene glycol) (peg) to an animal, composition pharmaceuticals, kits for the prevention or therapeutic treatment of bowel-derived sepsis, and for monitoring the administration of poly (ethyle