首页> 外国专利> Isolated human monoclonal antibody, methods for inhibiting tnfa production in t cells or monocytes and t cell proliferation, hybridoma, transfectoma, transgenic non-human animal, method for producing a human monoclonal antibody, pharmaceutical composition, methods for treating or preventing a human il-15 mediated disorder, psoriasis and rheumatoid arthritis, method for diagnosing a disease, nucleic acid, and expression vector

Isolated human monoclonal antibody, methods for inhibiting tnfa production in t cells or monocytes and t cell proliferation, hybridoma, transfectoma, transgenic non-human animal, method for producing a human monoclonal antibody, pharmaceutical composition, methods for treating or preventing a human il-15 mediated disorder, psoriasis and rheumatoid arthritis, method for diagnosing a disease, nucleic acid, and expression vector

机译：分离的人单克隆抗体，抑制t细胞或单核细胞中tnfa产生和t细胞增殖的方法，杂交瘤，转染瘤，转基因非人动物，人单克隆抗体的生产方法，药物组合物，治疗或预防人il-的方法15种介导的疾病，牛皮癣和类风湿性关节炎，疾病的诊断方法，核酸和表达载体

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"ISOLATED HUMAN MONOCLONAL ANTIBODY, METHODS TO INHIBIT TNF 244 PRODUCTION IN T OR MONOCYTE CELLS AND T-CELL PROLIFERATION, HYBRIDOMA, TRANSFECTOMA, NON-HUMAN TRANSGENOUS, HUMAN TRANSMETHYNAMOUS, MONODYNAMOUS, HUMAN ANTIBODIES TREATMENT OR PREVENTION OF A HUMAN IL-15-MEDIATED DISORDER, PSORIASIS AND RHEUMATIOUS ARTHRITIS, A METHOD FOR DIAGNOSING A DISEASE, NUCLEIC ACID, AND EXPRESSION VECTOR ". Isolated human monoclonal antibodies that specifically bind to IL-15 (e.g., human IL-15) and related antibody-based compositions and molecules are disclosed. Human antibodies can be produced in a transfectome or non-human transgenic animal, for example, a transgenic mouse capable of producing multiple isotypes of human monoclonal antibodies by V-D-J recombination and changing the isotype. Also disclosed are pharmaceutical compositions comprising human antibodies, non-human transgenic animals and hybridomas producing human antibodies and diagnostic and therapeutic methods for using human antibodies.

机译：“分离的人单克隆抗体，抑制在T或单核细胞中生产TNF和抑制T细胞增殖的方法，T细胞增殖，杂交，非全人类，人类透支，单核，人类窦房结15介导的疾病，牛皮癣和风湿性关节炎，一种诊断疾病，核酸和表达载体的方法”。公开了特异性结合IL-15的分离的人单克隆抗体（例如人IL-15）和相关的基于抗体的组合物和分子。可以在转染子或非人转基因动物中产生人抗体，例如，能够通过V-D-J重组并改变同种型而产生人单克隆抗体的多种同种型的转基因小鼠。还公开了包含人抗体，产生人抗体的非人转基因动物和杂交瘤的药物组合物以及使用人抗体的诊断和治疗方法。

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公开/公告号BR0212136A

专利类型
公开/公告日2004-12-07

原文格式PDF
申请/专利权人 GENMAB A/S;
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申请/专利号BR20020212136
发明设计人 JAN G. J. VAN DE WINKEL;MARCUS ANTONIUS VAN DIJK;JANINE SCHUURMAN;ARNOUT F. GERRITSEN;OLE BAADSGAARD;
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申请日2002-08-23
分类号C12N5/10;C12N5/12;C12N5/16;C12N5/18;C12N15/12;C12N15/63;C07K14/47;C07K16/24;A61K39/395;A61K39/44;C12N15/64;
国家 BR
入库时间 2022-08-21 22:18:43

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