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首页> 外国专利> nucleic acid, polypeptide, vector, cell, antibody, methods of diagnosing a phenotype and a patient as expressing a nucleic acid and of identifying agents that modulate the activity of a nucleic acid and a protein and lrp5, lrp6, or hbm and compounds that modulate the interaction of dkk with the wnt signaling path, composition to modulate bone mass and / or lipid levels in a patient, transgenic animal, embryo and animal model, and, agent

nucleic acid, polypeptide, vector, cell, antibody, methods of diagnosing a phenotype and a patient as expressing a nucleic acid and of identifying agents that modulate the activity of a nucleic acid and a protein and lrp5, lrp6, or hbm and compounds that modulate the interaction of dkk with the wnt signaling path, composition to modulate bone mass and / or lipid levels in a patient, transgenic animal, embryo and animal model, and, agent

机译：核酸，多肽，载体，细胞，抗体，诊断表型和患者表达核酸的方法以及调节核酸和蛋白质和lrp5，lrp6或hbm活性的鉴定剂以及调节化合物dkk与wnt信号通路的相互作用，调节患者骨质量和/或脂质水平的成分，转基因动物，胚胎和动物模型以及药剂

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摘要

"NUCLEIC ACID, POLYPEPTID, VECTOR, CELL, ANTIBODY, METHODS OF DIAGNOSING A PHENOTYPE AND A PATIENT AS EXPRESSING NUCLEIC ACID AND IDENTIFYING AGENTS THAT MODULATE THE ACTIVITY OF A NUCLEIC AND LUCUS PROTEIN AND A LUCUS MODULATE DKK INTERACTION WITH THE WNT SIGNALING PATH, COMPOSITION FOR MODULATING BONE MASS AND / OR LIPID LEVELS IN A PATIENT, TRANSGENIC ANIMAL, EMBRYO AND ANIMAL MODEL, AND, AGENT ". The present invention relates to methods and materials used to express a polypeptide such as HBM derived from HBM, LRP5 or LRP6 in transgenic animal and animal cells. The present invention also relates to transgenic animals expressing polypeptides as HBM. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases. involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
机译：“核酸，多肽，载体，细胞，抗体，诊断表型和患者的表达核酸的方法，并鉴定能调节核酸和润滑蛋白的活性，并修饰带有DKK的核糖核酸通路的活性用于在患者，转基因动物，胚胎和动物模型以及代理商中调节骨骼质量和/或脂质水平。本发明涉及用于在转基因动物和动物细胞中表达衍生自HBM，LRP5或LRP6的多肽如HBM的方法和材料。本发明还涉及表达多肽作为HBM的转基因动物。本发明提供了核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定参与骨骼发育的分子的方法以及诊断和治疗疾病的方法。参与骨骼发育和脂质调节。在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

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