首页> 外国专利> Analgesic composition comprising an alpha adrenergic agonist agonist activity with a minimum use of alpha 2 and alpha adrenergic agonist and an antagonist Selective alfa-2a for preparing Pharmaceutical compositions for alleviating Pain

Analgesic composition comprising an alpha adrenergic agonist agonist activity with a minimum use of alpha 2 and alpha adrenergic agonist and an antagonist Selective alfa-2a for preparing Pharmaceutical compositions for alleviating Pain

机译：用于制备减轻疼痛的药物组合物的止痛组合物，其包含α肾上腺素能激动剂激动剂活性并最少使用α2和α肾上腺素能激动剂以及拮抗剂选择性α2a。

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摘要

Analgesic composition comprising an alpha adrenergic agonist agonist activity with a minimum agonist alfa-2a, that has the ability to produce Peripheral analgesia without concomitant sedation.Use of an alpha adrenergic agonist and an antagonist Selective alfa-2a to prepare a First and a Second Pharmaceutical composition for application on a method to relieve pain in a Mammal by administering to the Mammal that bought the first Pharmaceutical composition Therefore, an effective amount of the Alpha adrenergic agonist and, eventually,The Second Pharmaceutical composition comprising an effective amount of the selective antagonist alfa-2a.Aims to achieve lasting Relief of chronic pain in a Mammal by Activating the same receptor Analgesic Alpha adrenergic receptor activation in the absence of alpha - 2a for a period of at least three days, so that the relief of chronic pain is maintained in the aus Gum of the continuous Activation of this receptor.Alpha adrenergic receptor Analgesic can be, for example, The receptor alpha - 2b.

机译：包含α肾上腺素能激动剂激动剂活性和最小激动剂alfa-2a的镇痛剂组合物，其具有在不伴随镇静的情况下产生周围镇痛的能力。α肾上腺素能激动剂和拮抗剂选择性α2-2a在制备第一和第二药物中的用途用于通过向购买了第一药物组合物的哺乳动物给药来减轻哺乳动物疼痛的方法中使用的组合物，因此，有效量的阿尔法肾上腺素能激动剂以及最终的第二药物组合物包含有效量的选择性拮抗剂α -2a。目的是通过在不存在α-2a的情况下激活相同的受体镇痛药α-肾上腺素能受体激活至少三天，从而持续缓解哺乳动物的慢性疼痛，从而保持慢性疼痛的缓解。持续激活该受体的口香糖。α肾上腺素受体镇痛药可以是例如，受体alpha-2b。

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公开/公告号AR040038A1

专利类型
公开/公告日2005-03-09

原文格式PDF
申请/专利权人 ALLERGAN INC.;
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申请/专利号AR2003P101753
发明设计人
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申请日2003-05-20
分类号A61K31/538;A61K31/4164;A61K31/4168;A61K31/4178;A61K31/498;A61K31/137;A61P29/00;
国家 AR
入库时间 2022-08-21 22:18:51

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