首页> 外国专利> Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same

Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same

机译:稳定的增加杀菌/通透性的蛋白质产品和含有该蛋白质产品的药物组合物

摘要

Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.
机译:公开了新型杀菌/增加通透性(BPI)蛋白产品,其中半胱氨酸残基编号132或135被另一个氨基酸残基,优选丙氨酸或丝氨酸残基代替,和/或其中在193位的亮氨酸残基为羧基末端残基。还公开了编码在合适的宿主细胞中产生DNA的方法的DNA序列,以及含有适合用于革兰氏阴性细菌感染及其后遗症治疗的类似物的稳定的均质药物组合物。

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