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Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same
Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same
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机译:稳定的增加杀菌/通透性的蛋白质产品和含有该蛋白质产品的药物组合物
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摘要
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.
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