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Induction of the formation of insulin-producing cells via gene transfer of pancreatic beta-cell-associated transcriptional factor
Induction of the formation of insulin-producing cells via gene transfer of pancreatic beta-cell-associated transcriptional factor
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机译：通过胰腺β细胞相关转录因子的基因转移诱导胰岛素产生细胞的形成
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摘要
The present invention provides a method of inducing the formation of insulin-producing cells which comprises transferring a pancreatic β-cell associated transcriptional factor gene into the pancreas to induce the formation of insulin-producing cells. The pancreatic β-cell associated transcriptional factor gene is transferred into the pancreatic tissue stem cells by the ICBD injection without ligating the common bile ducts and thus the formation of insulin-producing cells is induced. In the present invention, pdx-1, neurogenin3, etc. are used as such pancreatic β-cell associated transcriptional factor gene and an adenoviral vector with the use of the Cre-loxP recombination system, etc. is used as a vector for transferring the pancreatic β-cell associated transcriptional factor gene into the pancreas. The method of the invention enables regeneration therapy for diabetes mellitus by inducing the formation of insulin-producing cells.
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