embedded image"/> Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
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Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease

机译:放射性示踪剂,用于体内研究乙酰胆碱酯酶和阿尔茨海默氏病

摘要

Methods for detecting acetylcholinesterase in a brain of a patent, comprising administering to the patient a detectable amount of a radiolabeled compound of a class of benzisoxazoles or a pharmaceutically acceptable salt thereof, are disclosed herein. The methods are useful for diagnosing, estimating the severity of, or monitoring the progression of a dementia, such as Alzheimer's disease, in a patient. In a preferred embodiment, the benzisoxazole is: embedded image
机译:本文公开了一种用于检测专利的大脑中的乙酰胆碱酯酶的方法,该方法包括向患者施用可检测量的一类苯并异恶唑的放射性标记化合物或其药学上可接受的盐。该方法可用于诊断,估计患者的痴呆症例如阿尔茨海默氏病的严重性或监测其进展。在一个优选的实施方案中,苯并异恶唑为: <图像alt =“嵌入式图像” file =“ US20050100509A1-20050512-C00001.GIF” he =“ 30.40mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 65.11mm“ />

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