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Algorithm for estimating and testing association between a haplotype and quantitative phenotype
Algorithm for estimating and testing association between a haplotype and quantitative phenotype
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机译：估计和测试单倍型和定量表型之间的关联的算法
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摘要
A method of estimating, in addition to haplotype frequencies and diplotype configurations, a means and a standard deviation determining a distribution of a quantitative phenotype by the diplotype on the basis of data on observed genotypes and phenotype data taking a continuous value. The method includes a step a of calculating the maximum likelihood (L0max) on the basis of genotype data and phenotype data taking a continuous value by using as parameters haplotype frequencies and a means and a standard deviation determining a distribution of a quantitative phenotype, under the hypothesis that there is no association between a diplotype configuration including a predetermined haplotype and a predetermined phenotype, and maximum likelihood estimates and the maximum likelihood (Lmax) of haplotype frequencies and penetration rate obtained by maximizing the likelihood under the hypothesis that there is an association between the diplotype configuration including the predetermined haplotype and the phenotype distribution taking a continuous value, and a step b of obtaining the means and the standard deviation determining a distribution of a quantitative phenotype from the maximum likelihood estimates obtained in the step a.
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机译：除了估计单倍型频率和双倍型构型之外，一种方法和标准偏差用于基于观察到的基因型数据和具有连续值的表型数据，通过双倍型确定定量表型的分布的方法和标准偏差。该方法包括步骤a，基于基因型数据和表型数据，通过使用单倍型频率作为参数，采用取连续值的基因型数据和表型数据，计算最大似然（L 0max ），以及确定a的平均值和标准差。在包括预定单倍型和预定表型的双倍型构型与最大似然估计和单倍型频率的最大似然估计和最大似然（L max ）之间不存在关联的假设下，定量表型的分布在假设包含预定单倍型的双倍型构型和具有连续值的表型分布之间存在关联的假设下，通过最大化似然性而获得的渗透率，以及获得均值和标准差以确定定量分布的步骤b从步骤a中获得的最大似然估计值中提取表型。
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