首页> 外国专利> Use of cross-linked and covalently bound urokinase-type plasminogen activator (scuPA) -urokinase-type plasminogen activator receptor (suPAR) complex as fibrinolytic agent

Use of cross-linked and covalently bound urokinase-type plasminogen activator (scuPA) -urokinase-type plasminogen activator receptor (suPAR) complex as fibrinolytic agent

机译：交联和共价结合的尿激酶型纤溶酶原激活物（scuPA）-尿激酶型纤溶酶原激活物受体（suPAR）复合物作为纤溶剂的用途

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摘要

The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR complex in the prevention and/or treatment of thrombolytic disorders. The invention further relates to combination compositions and/or therapy regimens, comprising the cross-linked scuPA/suPAR complex or tcuPA/suPAR and one or more currently used plasminogen activators to achieve improved therapeutic efficacy and/or reduce side effects.

机译：本发明涉及交联的scuPA / suPAR复合物和/或tcuPA / suPAR的交联复合物，具有纤溶活性的共价结合的单一化合物的制备方法以及交联的scuPA / suPAR或tcuPA /的用途。 suPAR复合物可预防和/或治疗溶栓性疾病。本发明进一步涉及组合物组合物和/或治疗方案，其包含交联的scuPA / suPAR复合物或tcuPA / suPAR和一种或多种当前使用的纤溶酶原激活剂，以实现改善的治疗功效和/或减少副作用。

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公开/公告号JP2004534837A

专利类型
公开/公告日2004-11-18

原文格式PDF
申请/专利权人スロンボテックリミテッド;
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申请/专利号JP20030511634
发明设计人ヒガジアブドアル－ルーフ;
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申请日2002-06-24
分类号C07K14/745;A61K38/00;A61K38/48;A61P3/06;A61P3/10;A61P7/00;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P11/00;C07K14/705;C07K19/00;C12N9/72;
国家 JP
入库时间 2022-08-21 22:28:12

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