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method of identifying a modulator of gene expression and bbc3 apoptosis using bbc3 gene promoter and gene promoter bbc3

机译:bbc3基因启动子和基因启动子bbc3鉴定基因表达和bbc3凋亡调控因子的方法

摘要

The present invention relates to a method for measuring a change in the apoptotic properties of the cell or by changes in the expression of the reporter gene or genes bbc3, to identify compounds that modulate directly or indirectly apoptosis. The invention also relates to methods of identifying compounds that interact with the promoter of the gene bbc3 and methods of identifying compounds that modulate the expression of genes bbc3. In addition, how to modulate apoptosis of cells, how to modulate bbc3 gene expression in cells, how to make a modulator of apoptosis, and the present invention relates to a process for making a modulator of bbc3 gene expression. Finally, the invention relates to sequences homologous thereto and the promoter of the gene and bbc3 compounds were identified by each of the methods of the present invention.
机译:本发明涉及一种用于测量细胞凋亡特性的变化或通过报告基因或多个基因bbc3的表达变化的方法,以鉴定直接或间接调节细胞凋亡的化合物。本发明还涉及鉴定与基因bbc3的启动子相互作用的化合物的方法和鉴定调节基因bbc3的表达的化合物的方法。另外,如何调节细胞凋亡,如何调节细胞中的bbc3基因表达,如何制备凋亡的调节剂,本发明涉及制备bbc3基因表达的调节剂的方法。最后,本发明涉及与其同源的序列,并且通过本发明的每种方法鉴定了基因的启动子和bbc3化合物。

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