首页> 外国专利> Detection of autoantibodies against 18 protein cytokeratin in patients with chronic rhinitis and bronchial asthma, and applications, including chronic rhinitis diagnostic kits and bronchial asthma including 18 protein cytokeratin mammalian

Detection of autoantibodies against 18 protein cytokeratin in patients with chronic rhinitis and bronchial asthma, and applications, including chronic rhinitis diagnostic kits and bronchial asthma including 18 protein cytokeratin mammalian

机译：慢性鼻炎和支气管哮喘患者抗18蛋白细胞角蛋白的自身抗体的检测及其应用，包括慢性鼻炎诊断试剂盒和包括18种蛋白细胞角蛋白的哺乳动物的支气管哮喘

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摘要

The present invention is based on the surprising discovery of autoantibodies to cytokeratin 18 protein in the serum samples of patients with bronchial asthma and chronic rhinitis, especially in nonallergic patients. The present invention includes diagnostic methods and a diagnostic kit to detect patients with bronchial asthma and chronic rhinitis associated with autoantibodies to cytokeratin 18. The invention also includes methods and kits to prescribe or monitor treatment for patients with bronchial asthma and chronic rhinitis by detecting autoantibodies to cytokeratin 18. The present invention also includes a pharmaceutical formulation comprising cytokeratin 18 protein to protect patients with bronchial asthma and chronic rhinitis associated with autoantibodies to cytokeratin 18. The present invention also includes methods to treat patients with bronchial asthma and chronic rhinitis associated with autoantibodies to cytokeratin 18 using compounds that inhibit the interaction between such autoantibodies and cytokeratin 18 protein.

机译：本发明基于在患有支气管哮喘和慢性鼻炎的患者，特别是非过敏性患者的血清样品中对细胞角蛋白18蛋白自身抗体的令人惊讶的发现。本发明包括诊断方法和诊断试剂盒，以检测与细胞角蛋白18自身抗体有关的支气管哮喘和慢性鼻炎患者。细胞角蛋白18。本发明还包括包含细胞角蛋白18蛋白的药物制剂，以保护患有支气管哮喘和与自身抗体相关的慢性鼻炎的患者。本发明还包括治疗患有支气管哮喘和与自身抗体相关的慢性鼻炎的患者的方法。 cytokeratin 18使用抑制此类自身抗体与cytokeratin 18蛋白相互作用的化合物。

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公开/公告号JP2005531754A

专利类型
公开/公告日2005-10-20

原文格式PDF
申请/专利权人ナン、ドン－ホ;チョン、スク－ヨン;
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申请/专利号JP20040505686
发明设计人ナン、ドン－ホ;チョン、スク－ヨン;
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申请日2003-05-12
分类号G01N33/53;A61K38/00;A61K39/00;A61P11/02;A61P11/06;G01N33/15;G01N33/50;
国家 JP
入库时间 2022-08-21 22:31:33

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