首页> 外国专利> A170 GENE KNOCKOUT MOUSE AS INSULIN-RESISTANT DISEASE MODEL, AND METHOD USING THE KNOCKOUT MOUSE

A170 GENE KNOCKOUT MOUSE AS INSULIN-RESISTANT DISEASE MODEL, AND METHOD USING THE KNOCKOUT MOUSE

机译:A170基因敲除小鼠作为胰岛素抵抗疾病模型,以及使用该基因敲除小鼠的方法

摘要

PPROBLEM TO BE SOLVED: To provide an insulin-resistant disease model mouse exhibiting symptoms similar to human insulin-resistant diseases including food intake increase, hyperlipidemia, fatty liver, obesity and hyperinsulinemia, and to provide a screening method using the model mouse. PSOLUTION: The A170 gene knockout mouse as an insulin-resistant disease model is provided. The screening method using the A170 gene knockout mouse is also provided, comprising screening therapeutic agents for insulin-resistant diseases. The A170 gene knockout mouse exhibits not only insulin resistance but also symptoms similar to human insulin-resistant diseases including obesity and fatty liver. PCOPYRIGHT: (C)2006,JPO&NCIPI
机译:

要解决的问题:提供一种胰岛素抵抗性疾病模型小鼠,表现出与人类胰岛素抵抗性疾病相似的症状,包括食物摄入增加,高脂血症,脂肪肝,肥胖症和高胰岛素血症,并提供使用该模型小鼠的筛选方法。

解决方案:提供了A170基因敲除小鼠作为胰岛素抵抗性疾病模型。还提供了使用A170基因敲除小鼠的筛选方法,其包括筛选针对胰岛素抵抗性疾病的治疗剂。 A170基因敲除小鼠不仅表现出胰岛素抵抗,而且还表现出类似于人类胰岛素抵抗疾病的症状,包括肥胖和脂肪肝。

版权:(C)2006,JPO&NCIPI

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