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Dispersing water-soluble or hydrophilic substances in supercritical fluid, useful in encapsulation of pharmaceuticals, by adding polymeric surfactant that contains carbon dioxide-philic and hydrophilic blocks
Dispersing water-soluble or hydrophilic substances in supercritical fluid, useful in encapsulation of pharmaceuticals, by adding polymeric surfactant that contains carbon dioxide-philic and hydrophilic blocks
Process for dispersing water-soluble or hydrophilic substances (I) in a fluid (II) at supercritical pressure by adding a surfactant (III) that is a block copolymer comprising a CO-2-philic block (B1) and a nonionic hydrophilic block (B2). Independent claims are also included for the following: (1) method for encapsulating an active agent that includes the new dispersion process; and (2) block copolymer that comprises B1 and a biocompatible B2.
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