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Method of preparation of microparticles without solvent, toxic epidermal necrolysis, microparticles obtained according to this process, and pharmaceutical compositions
Method of preparation of microparticles without solvent, toxic epidermal necrolysis, microparticles obtained according to this process, and pharmaceutical compositions
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机译:没有溶剂的微粒的制备方法,有毒的表皮坏死溶解,根据该方法获得的微粒以及药物组合物
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摘要
Method for preparation of solid microparticles containing at least one active ingredient (I). Method for preparation of solid microparticles containing at least one active ingredient (I) comprises (a) making a solution (A) of at least one biodegradable, biocompatible and water-insoluble polymer (P) in a biocompatible and water-miscible solvent (S); (b) dissolving or suspending at least one hydrophilic or hydrophobic (I) in the solution, forming (B); (c) emulsifying (B), optionally in presence of a surfactant, in a plant oil that forms the continuous hydrophobic phase; and (d), the new feature, extraction of (S) by adding at least one biocompatible hydrophobic oil (O), with gentle stirring, until solid microparticles of (P), containing (I), have formed. An Independent claim is also included for microparticles (MP) containing (I) prepared by the new method.
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