首页> 外国专利> PROCEDURES FOR MODUCING THE NEOVAKCULATION AND/OR THE GROWTH OF COLLATERAL SPECIES AND/OR OTHER SPECIES FROM EXISTING SPECIALS

PROCEDURES FOR MODUCING THE NEOVAKCULATION AND/OR THE GROWTH OF COLLATERAL SPECIES AND/OR OTHER SPECIES FROM EXISTING SPECIALS

机译:用于调节现有物种的新物种和/或分生物种和/或其他物种的生长的程序

摘要

Described is the modulation of the neovascularization and/or growth of collateral arteries and/or other arteries from preexisting arteriolar connections. Methods are provided for enhancing neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections comprising contacting organs, tissue or cells with a colony stimulating factor (CSF) or a nucleic acid molecule encoding said CSF. Furthermore, the use of a CSF or a nucleic acid molecule encoding said CSF for the preparation of pharmaceutical compositions for enhancing neovascularization and/or collateral growth of collateral arteries and/or other arteries from preexisting arteriolar connections is described. Also provided are methods for the treatment of tumors comprising contacting an organ, tissue or cells with an agent which suppresses neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections through the inhibition of the biological activity of CSFs. Described is further the use of an agent which suppresses neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections through inhibition of the biological activity of CSFs for the preparation of pharmaceutical compositions for the treatment of tumors.
机译:描述了来自先前存在的小动脉连接的新血管形成和/或侧支动脉和/或其他动脉的生长。提供了用于增强新血管形成和/或来自先前存在的小动脉连接的侧支动脉和/或其他动脉的生长的方法,这些连接包括使器官,组织或细胞与集落刺激因子(CSF)或编码所述CSF的核酸分子接触。此外,描述了CSF或编码所述CSF的核酸分子在制备药物组合物中的用途,所述药物组合物用于增强从先前存在的小动脉连接的副动脉和/或其他动脉的新血管形成和/或侧枝生长。还提供了用于治疗肿瘤的方法,该方法包括使器官,组织或细胞与通过抑制CSF的生物学活性而抑制新血管形成和/或附带小动脉和/或其他动脉的生长的试剂接触先前存在的小动脉连接。还描述了通过抑制CSF的生物学活性来抑制先前存在的小动脉连接的新血管形成和/或侧支动脉和/或其他动脉的生长的药物在制备用于治疗肿瘤的药物组合物中的用途。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号