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PROCEDURES FOR MODUCING THE NEOVAKCULATION AND/OR THE GROWTH OF COLLATERAL SPECIES AND/OR OTHER SPECIES FROM EXISTING SPECIALS
PROCEDURES FOR MODUCING THE NEOVAKCULATION AND/OR THE GROWTH OF COLLATERAL SPECIES AND/OR OTHER SPECIES FROM EXISTING SPECIALS
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机译:用于调节现有物种的新物种和/或分生物种和/或其他物种的生长的程序
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摘要
Described is the modulation of the neovascularization and/or growth of collateral arteries and/or other arteries from preexisting arteriolar connections. Methods are provided for enhancing neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections comprising contacting organs, tissue or cells with a colony stimulating factor (CSF) or a nucleic acid molecule encoding said CSF. Furthermore, the use of a CSF or a nucleic acid molecule encoding said CSF for the preparation of pharmaceutical compositions for enhancing neovascularization and/or collateral growth of collateral arteries and/or other arteries from preexisting arteriolar connections is described. Also provided are methods for the treatment of tumors comprising contacting an organ, tissue or cells with an agent which suppresses neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections through the inhibition of the biological activity of CSFs. Described is further the use of an agent which suppresses neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections through inhibition of the biological activity of CSFs for the preparation of pharmaceutical compositions for the treatment of tumors.
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