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Expression of heterologous genes according to a target - noticeable similarity in expression profile

机译：根据靶标表达异源基因-表达谱中明显相似

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摘要

A DNA construct is described containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is bounded at 5' and 3' ends by DNA sequences that enable homologous recombination or integration of the construct with the DNA of a targeted host to obtain expression of the heterologous gene in the host.

机译：描述了一种DNA构建体，其包含与异源基因序列偶联的内部核糖体结合位点（IRES）的表达单元;该表达单元在5'和3'末端被DNA序列所束缚，该DNA序列使得该构建体能够与靶宿主的DNA进行同源重组或整合，从而在宿主中获得异源基因的表达。

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公开/公告号DE69433034T2

专利类型
公开/公告日2004-06-09

原文格式PDF
申请/专利权人 UNIVERSITY OF EDINBURGH SOUTH BRIDGE EDINBURGH GB;
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申请/专利号DE1994633034T
发明设计人 SMITH GERARD AUSTIN WEST MAIN ROAD EDINBURGH EH9 3JQ GB;MOUNTFORD SCOTT PETER MELBOURNE AU;LATHE FRANK RICHARD WEST MAIN ROAD EDINBURGH EH9 3JQ GB;
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申请日1994-04-21
分类号C12N15/90;A01K67/027;C12N15/00;C12N5/10;C12N15/12;C12N15/19;C12N15/15;
国家 DE
入库时间 2022-08-21 22:41:10

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