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Protein fragments from the central region of the flagellin from Borrelia burgdorferi, suitable as antigens for the specific detection of antibodies and methods for their production

机译：来自伯氏疏螺旋体的鞭毛蛋白中心区的蛋白质片段，适合作为特异性检测抗体的抗原及其生产方法

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摘要

New protein fragments (I), from the aminoacid 132-266 region of the flagellin of Borrelia burgdorferi, are encoded by DNA sequences which hybridise with the sequence of formula (I). USE/ADVANTAGE - (I) are used an antigens for sensitive and specific in vitro detection of antibodies specific for Lyme borrelosis Antisera raised against them show no cross-reactivity with flagellin proteins of other species (except weak reactivity with some other Borrelia species of little significance in Europe), i.e. (I) do not produce false positive in the same was as intact flagellin. Since (I) are small, microlitre plates coated with them can bind more specific antibodies than plates coated with flagellin, providing at least 3-fold increase in sensitivity.

机译：来自伯氏疏螺旋体鞭毛蛋白氨基酸132-266区域的新蛋白质片段（I）由与式（I）的序列杂交的DNA序列编码。使用/优势-（I）用于抗原的灵敏和特异的体外检测，对莱姆氏菌病具有特异性。针对它们的抗血清显示与其他物种的鞭毛蛋白没有交叉反应（除了与其他极少的疏螺旋体的反应性弱）在欧洲具有重要意义），即（I）不会产生与完整鞭毛相同的假阳性。由于（I）很小，包被它们的微升板比包被鞭毛蛋白的板可以结合更多的特异性抗体，从而使灵敏度至少提高了三倍。

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公开/公告号DE4120345C5

专利类型
公开/公告日2004-08-12

原文格式PDF
申请/专利权人 VOGT ARNOLD PROF. DR.MED. 79283 BOLLSCHWEIL DE;
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申请/专利号DE19914120345
发明设计人 RASIAH CHRISTIANE DIPL.-BIOL. 7800 FREIBURG DE;GASSMANN GABRIELE DIPL.-BIOL. DR. 7801 EBRINGEN DE;VOGT ARNOLD PROF. DR.MED. 79283 BOLLSCHWEIL DE;
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申请日1991-06-19
分类号C07K14/195;C07H21/04;C07K16/12;G01N33/569;C12P21/06;C12Q1/00;
国家 DE
入库时间 2022-08-21 22:42:16

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