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New 4-alkoxymethyl-cyclohexylamine derivatives, useful as e.g. ORL1 receptor ligands for treating e.g. anxiety, depression, epilepsy, senile dementia, withdrawal symptoms or especially pain
New 4-alkoxymethyl-cyclohexylamine derivatives, useful as e.g. ORL1 receptor ligands for treating e.g. anxiety, depression, epilepsy, senile dementia, withdrawal symptoms or especially pain
1-Substituted 4-alkoxymethyl-cyclohexylamine derivatives (I) are new. Cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new; R1, R2 = H, Alk, Cyc, Ar, Het, -Q1-Ar, -Q1-Cyc' or -Q1-Het; or NR1R2 = morpholino, 4-(R6)-piperazino, azetidino, pyrrolidino, piperidino or homopiperidino; Alk = optionally unsaturated, optionally mono- or polysubstituted 1-8C alkyl; Cyc = optionally unsaturated, optionally mono- or polysubstituted 3-8C cycloalkyl; Cyc' = optionally mono- or polysubstituted 3-8C cycloalkyl; Ar = optionally mono- or polysubstituted aryl; Het = optionally mono- or polysubstituted heteroaryl; Q1 = 1-3C alkylene; R6 = as for R1; R3 = Alk, Cyc, Ar, Het, -Q2-Ar, -Q2-Cyc' or -Q2-Het ; Q2 = optionally unsaturated, optionally substituted 1-4C alkylene; R5 = Cyc', Ar, Het, -CH2R12, -(CH2)2R12 or -(CH2)3R12; R12 = Cyc', Ar or Het. Independent claims are also included for the preparation of (I).
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