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METHOD FOR PROGNOSTICATION OF EFFECTIVENESS IN USING ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

机译：血管紧张素转化酶抑制剂的药效预测方法

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摘要

FIELD: medicine, clinical pharmacology, biochemistry.;SUBSTANCE: invention proposes the developed method for prognostication of effectiveness of angiotensin-converting enzyme inhibitors that involves determination of blood serum concentration of diene conjugates. Method involves additional determination of the parent indices of heart state in patient: systolic arterial pressure, final systolic volume, final diastolic volume of left ventricle and these indices are determined during carrying out the orthostatic test. Patient is examined on orthotable with shifting the orthotable head end up by 60^o and kept in this position for 10 min. On 5-th min of orthostatic position heart state indices are determined in the patient again followed by calculations of the venous reflux coefficient (K_VR) is measured by the formula and coefficient of vascular response (K_vr) also. The favorable result for effectiveness in using preparations of the group of angiotensin-converting enzyme inhibitors is determined at value K_VR from 0.7 to 0.95 and value K_vr from 0.8 to 0.95, and the concentration of diene conjugates less 10 mcM/ml. Method provides assay of quantitative evaluation of individual sensitivity of patient to preparations of the group of angiotensin-converting enzyme inhibitors.;EFFECT: improved method for prognostication.;2 ex

机译：领域：发明提出了用于预测血管紧张素转化酶抑制剂有效性的已开发方法，该方法涉及确定二烯缀合物的血清浓度。该方法还需要另外确定患者的心脏状态的父母指标：收缩压，最终收缩容积，左心室最终舒张容积，这些指数是在进行体位测试时确定的。对患者进行可检查的检查，将可检查的头部向上移动60 ^{o ，并在该位置保持10分钟。在坐立位的第5分钟，再次确定患者的心脏状态指标，然后通过公式计算血管反流系数（K _{VR ）和血管反应系数（K _{vr ）。确定将K _{VR 的值从0.7调至0.95和将K _{vr 的值从0.8调至0.95可以有效地使用一组血管紧张素转换酶抑制剂。和二烯共轭物的浓度小于10 mcM / ml。该方法提供了定量评估患者对一组血管紧张素转化酶抑制剂制剂敏感性的测定方法。效果：改进的预后方法。2}}}}}

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公开/公告号RU2237243C2

专利类型
公开/公告日2004-09-27

原文格式PDF
申请/专利权人
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申请/专利号RU20020132503
发明设计人 KOTELNIKOVA T.E.;TONKIKH E.V.;CHERNOV S.JU.;CHERNOV JU.N.;BATISHCHEVA G.A.;KALJUZHNAJA A.S.;MITICHKIN A.V.;
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申请日2002-12-04
分类号G01N33/48;A61B5/02;
国家 RU
入库时间 2022-08-21 22:44:52

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