首页> 外国专利> WATER-SOLUBLE CHEMICALLY DEGRADABLE N-VINYL-2-PYRROLIDONE/ALLYLAMINE COPOLYMERS CONTAINING AZOMETHYNE BONDS SHOWING BIOLOGICAL ACTIVITY, WATER- SOLUBLE CHEMICALLY DEGRADABLE N-VINYL-2-PYRROLIDONE/ALLYLAMINE COPOLYMERS CONTAINING AZOMETHYNE BONDS AS POLYMERS CARRIERS, AND A METHOD FOR PRODUCING WATER-SOLUBLE CHEMICALLY DEGRADABLE N-VINYL-2-PYRROLIDONE/ALLYLAMINE COPOLYMERS

WATER-SOLUBLE CHEMICALLY DEGRADABLE N-VINYL-2-PYRROLIDONE/ALLYLAMINE COPOLYMERS CONTAINING AZOMETHYNE BONDS SHOWING BIOLOGICAL ACTIVITY, WATER- SOLUBLE CHEMICALLY DEGRADABLE N-VINYL-2-PYRROLIDONE/ALLYLAMINE COPOLYMERS CONTAINING AZOMETHYNE BONDS AS POLYMERS CARRIERS, AND A METHOD FOR PRODUCING WATER-SOLUBLE CHEMICALLY DEGRADABLE N-VINYL-2-PYRROLIDONE/ALLYLAMINE COPOLYMERS

机译：含氮杂蒽键的水溶性可化学降解的N-乙烯基-2-吡咯烷酮/烯丙胺共聚物，具有生物活性，水溶性，可降解的N-乙烯基-2-吡咯烷酮/烯丙胺共聚物，由聚合物构成溶性可化学降解的N-乙烯基-2-吡咯烷酮/烯丙胺共聚物

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FIELD: polymer production. SUBSTANCE: invention provides water-soluble chemically degradable polymers having following structure: , in which R represents spiramycin antibiotic residue bond through its CHO group to amino group of polymer carrier, n= 91.6-93.9 mol %, m=6.2-8.4 mol %, k=0.8-5.6 mol %, and m-k= 2.8-6.2 mol %. Molecular weight of copolymers ranges between 25000 and 150000. Copolymers are prepared by reaction of linear N-vinyl-2-pyrrolidone/allylamine copolymers [molecular weight 8700-2000, N-vinyl- 2-pyrrolidone/allylamine molar ratio (91.6- 93.9):(6.1-8.4)] with glutaric aldehyde in aqueous solution at 40-50 C under inert gas atmosphere for 7-9 h, concentration of linear copolymer being 8.8- 12.0 wt %, molar ratio of glutaric aldehyde to amino group of copolymer being (0.075-0.15):1, and product of molar concentration of linear copolymer and above-indicated molar ratio in the course of reaction ranging between 0.88 and 1.58. EFFECT: enabled production of chemically degradable polymer compounds with variable biological activity. 3 cl, 1 tbl, 5 ex

机译：领域：聚合物生产。物质：本发明提供了具有以下结构的水溶性化学可降解聚合物：<图像文件=“ 00000002.GIF” he =“ 100” id =“ imag00000002” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 108” /> ，其中R代表通过其CHO基团与聚合物载体的氨基上的螺旋霉素抗生素残基键，n ＝ 91.6-93.9mol％，m ＝ 6.2-8.4mol％，k ＝ 0.8-5.6mol％，mk ＝ 2.8-6.2摩尔％。共聚物的分子量在25000和150000之间。共聚物是通过线性N-乙烯基-2-吡咯烷酮/烯丙胺共聚物[分子量8700-2000，N-乙烯基-2-吡咯烷酮/烯丙胺摩尔比（91.6-93.9）]制备的：（（6.1-8.4）]与戊二醛在惰性气氛下于40-50℃的水溶液中混合7-9h，线性共聚物的浓度为8.8-12.0wt％，戊二醛与共聚物的氨基的摩尔比为（0.075-0.15）：1，并且在反应过程中线性共聚物的摩尔浓度与上述摩尔比的乘积在0.88至1.58之间。效果：能够生产具有可变生物活性的可化学降解的高分子化合物。 3 cl，1 tbl，5前

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公开/公告号RU2218357C2

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公开/公告日2003-12-10

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申请/专利号RU20010111608
发明设计人 SOLOVSKIJ M.V.;NIKOLSKAJA N.V.;PAVLOV G.M.;MIKHAJLOVA N.A.;KORNEEVA E.V.;KEVER E.E.;NESTEROV V.V.;
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申请日2001-04-26
分类号C08F226/10;C08F226/04;C08G12/06;A61K31/7048;A61K47/48;A61P31/00;
国家 RU
入库时间 2022-08-21 22:45:20

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