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Infectious Japanese encephalitis virus cDNA clone and its vaccine to produce highly attenuated recombinant Japanese encephalitis virus

机译:传染性日本脑炎病毒cDNA克隆及其疫苗,可产生高度减毒的重组日本脑炎病毒

摘要

The present invention relates to a recombinant, attenuated Japanese encephalitis virus comprising a single amino acid variation in an envelope protein. Specifically, the present invention relates to an isolated DNA molecule encoding the genome of the Japanese encephalitis virus strain. The present invention also relates to a method for producing Japanese encephalitis virus strain from cultured animal cells. In addition, the present invention relates to a pharmaceutical composition for preventing toxic Japanese encephalitis virus.
机译:本发明涉及重组的减毒的日本脑炎病毒,其在包膜蛋白中包含单个氨基酸变异。具体地,本发明涉及编码日本脑炎病毒株的基因组的分离的DNA分子。本发明还涉及从培养的动物细胞生产日本脑炎病毒株的方法。另外,本发明涉及用于预防中毒性日本脑炎病毒的药物组合物。

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