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2 P450 NADPH- P450 Agent Containing CuII ion as an Effective Component to Inhibit Activities of Cytochrome P450 and NADPH-cytochrome P450 reductase
2 P450 NADPH- P450 Agent Containing CuII ion as an Effective Component to Inhibit Activities of Cytochrome P450 and NADPH-cytochrome P450 reductase
PURPOSE: An inhibitor of the activity of cytochrome P450 and NADPH-cytochrome P450 reductase containing cupric ion as an effective ingredient is provided. By the utilization of the inhibitor, the activity of P450 enzyme and NPR enzyme is simultaneously inhibited. CONSTITUTION: A agent for inhibiting the activity of cytochrome P450 enzyme and NADPH-cytochrome P450 reductase contains cupric ion to inhibit the activity at a protein level. Only the cupric ion of divalent cation metals containing Ca, Cu, Co, Mg, Mn, Zn or the like inhibits a P450 system. The inhibitor for cytochrome P450 activity can be used in simultaneously inhibiting all kinds of P450.
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