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Method of analysis of a table of data relating to expressions of genes and relative identification system of co-expressed and co-regulated groups of genes
Method of analysis of a table of data relating to expressions of genes and relative identification system of co-expressed and co-regulated groups of genes
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机译：分析与基因表达有关的数据表的方法以及共表达和共调控的基因组的相对鉴定系统
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摘要
A method for automatic analysis of the genomic information, in order to determine relationships among genes involved in a same regulating process allows to determine complex relationships among genes that go beyond the simple clustering operations of known methods aimed to determine co-expressed or co-regulated genes.;First a clustering algorithm is chosen and is applied to the table, obtaining sub-tables of data relative to groups of genes that satisfy the chosen clustering criterion. Therefore, all possible combinations of pair of sub-tables are generated and characteristic parameters are calculated for genes contained in these sub-tables. Finally, for each combination a characteristic value is calculated with a decision algorithm defined in function of these parameters, by considering the genes of the combination as constituting a 'Gene Network' if this characteristic value exceeds a pre-defined threshold.;The method is preferably is implemented by a relative system of identification of groups of co-expressed and co-rcgulated genes comprising an intelligent fuzzy sub-system trained off-line identified by a neural network.
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