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ZIS-SR NUCLEIC ACID AND AMINO ACID SEQUENCES INVOLVED IN THE REGULATED SECRETORY PATHWAY AND/OR THE REGULATION OF THE NEUROENDOCRINE PHENOTYPE (NEP)
ZIS-SR NUCLEIC ACID AND AMINO ACID SEQUENCES INVOLVED IN THE REGULATED SECRETORY PATHWAY AND/OR THE REGULATION OF THE NEUROENDOCRINE PHENOTYPE (NEP)
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机译：规管的分泌途径和/或神经内分泌表型（NEP）调控中涉及的ZIS-SR核酸和氨基酸序列
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摘要
The present invention relates to genes and protein encoded thereby that regulate the secretory pathway and/or the neuroendocrine phenotype (NEP) in cells and method of isolating same. More particularly, the present invention relates to long-term therapies for diseases or conditions associated with a loss function. More particularly, the present invention relates to the treatment of such diseases using a cell replacement therapy. In particular, the invention relates to genes involved in cellular differentiation and genes that modulate the formation of the regulated secretory pathway. The invention thus also concerns a method to identify such genes, the genes, variants or fragments thereof, vectors comprising same, the products of these genes, variants or fragments thereof and to cells expressing same. In a particular embodiment, the invention relates to the characterization of Zis-SR a novel sequence involved in the secretory pathway in cells.
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