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METHOD FOR TREATMENT AND PREVENTION OF ACUTE AND CHRONIC PSEUDOMONAS AERUGINOSA AIRWAY INFECTIONS WITH INHALABLE MACROLIDES
METHOD FOR TREATMENT AND PREVENTION OF ACUTE AND CHRONIC PSEUDOMONAS AERUGINOSA AIRWAY INFECTIONS WITH INHALABLE MACROLIDES
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机译：预防和预防可吸入性Macroolides急性和慢性铜绿假单胞菌感染的方法
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摘要
Macrolides, in particular azalides such as azithromycin, are suited for the treatment or prevention of acute or chronic P. aeruginosa infections of the airways by inhalation. The mechanism of action is the inhibition of the quorum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxodo1o decanoyl]-L-homoserine lactone and N-butyrylhomoserine lactone. This allows for inhalation treatments of P. aerugi-nosa infections at non-inhibiting concentrations of the macrolide.
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