A device for cleaving materials from solid supports, for example, contained within cans or other receptacles, comprises a block (2) in which (96) elongate receptacles (4) are defined. The receptacles are arranged to receive cans (20) which contain compounds prepared on solid supports in a combinatorial chemistry technique. Cleavage of compounds prepared is achieved by contacting the cans with a cleavage formulation, as a result of which the cleaved compound is present in a fluid which is present in the receptacle (4). Thereafter, the cleavage formulation is evaporated, leaving the compound cleaved in a solid form at the bottom (12) of the receptacle (4). The can (20) can then be removed and the compound which has been cleaved can be readily isolated.
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