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COMBINATIONS OF MEDICAMENTS COMPRISING AN ALCOHOL DETERRENT FOR TREATING ALCOHOL DEPENDENCE OR ALCOHOL ABUSE

机译:包含酒精洗涤剂的药物组合,用于治疗酒精依赖或酒精滥用

摘要

Alcohol disorders have been treated with a variety of therapies, including pharmaceutical. Benzodiazepines, are one type of pharmaceutical that has aided in treating the anxiety associated with alcohol disorders, however there are serious risks of abuse and dependence. Disulfiram is another pharmaceutical that provides a deterrent against consuming alcohol since it causes a person to become very ill when combined with alcohol. The deterrent effect of disulfiram is only effective when taken and non-compliance is a major limitation. This invention relates to a combination pharmaceutical medicine of disulfiram and a benzodiazepine that acts in an agonist-aversive manner for people with alcohol disorders. The combination of disulfiram and a benzodiazepine acts to reduce anxiety and deter alcohol consumption at the same time. This invention also relates to other combinations of agonist and aversive medicines to reduce anxiety and deter alcohol consumption. This invention also relates to aversive medicines combined with other agents to treat medical conditions, which medical conditions or agents' effectiveness are negatively impacted by the consumption of ethanol.
机译:酒精障碍已通过多种疗法进行了治疗,包括药物疗法。苯二氮卓类药物是一种有助于治疗与酒精障碍有关的焦虑症的药物,但是存在滥用和依赖性的严重风险。双硫仑是另一种可以阻止饮酒的药物,因为与酒精混合会导致人患重病。双硫仑的阻吓作用只有在服用时才有效,不遵守是主要的限制。双硫仑和苯并二氮杂的组合药物技术领域本发明涉及双硫仑和苯并二氮杂的组合药物,其以激动剂-平均的方式作用于酒精障碍患者。双硫仑和苯二氮卓类药物的组合可减少焦虑症,并同时阻止酒精的摄入。本发明还涉及激动剂和厌恶药的其他组合,以减少焦虑并阻止酒精的消耗。本发明还涉及与其他药物组合以治疗医学病症的厌恶药物,其中所述医学病症或试剂的有效性受到乙醇消耗的负面影响。

著录项

  • 公开/公告号WO2004054570A1

    专利类型

  • 公开/公告日2004-07-01

    原文格式PDF

  • 申请/专利权人 PUREPHARM INC.;

    申请/专利号WO2003CA00990

  • 发明设计人 DOYLE CHRISTOPHER S.;WASSENAAR WILLEM;

    申请日2003-06-25

  • 分类号A61K31/27;A61K31/5513;A61P25/32;A61K31/275;A61K31/485;A61K31/255;

  • 国家 WO

  • 入库时间 2022-08-21 22:55:41

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