首页> 外国专利> IMMUNOGENIC LIBRARY OF CHIMERIC PEPTIDES MIMICKING THE GENETIC DIVERSITY OF THE HYPERVARIABLE REGION V3 OF THE PROTEIN OF THE ENVELOPE OF A VIRUS GP 120 OF HUMAN IMMUNODEFICIENCY

IMMUNOGENIC LIBRARY OF CHIMERIC PEPTIDES MIMICKING THE GENETIC DIVERSITY OF THE HYPERVARIABLE REGION V3 OF THE PROTEIN OF THE ENVELOPE OF A VIRUS GP 120 OF HUMAN IMMUNODEFICIENCY

机译：嵌合肽的免疫原性文库，模拟人免疫缺陷病毒GP 120外壳蛋白的高变区V3的遗传多样性

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摘要

The invention relates to medicine and biotechnology, in particular to the diagnosis and preventive vaccination against AIDS-1 and can be used for producing antigens for diagnostic test-systems and for producing a vaccine against AIDS-1. The inventive immunogenic library of chimeric peptides mimicking the genetic diversity of the hypervariable region V3 gp120 AIDS-1 is embodied in such a way that it is immunogenic, initiates the production of antibodies interacting with a wide spectrum of gp120 variants of various genotypes of AIDS-1 and exhibits the capacity to bind earlier antibodies to AIDS-1. The structural composition of the library is disclosed in the description thereof. The capacity of the immunologic library of chimeric peptides to bind specific antibodies against AIDS-1 is studied with the aid of the indirect variant of an immunoassay analysis of the serum of AIDS-1 infected persons in comparison with the serum of healthy persons and the serum of standard anti- AIDS-1 panels. The immunisation of laboratory animals by the library of chimeric peptides produces specific antibodies interacting with a wide spectrum of gp 120 variants of various genotypes of human immunodeficiency.

机译：本发明涉及医学和生物技术，尤其涉及针对AIDS-1的诊断和预防接种，并可用于生产用于诊断测试系统的抗原和用于生产针对AIDS-1的疫苗。模仿高变区V3 gp120 AIDS-1遗传多样性的嵌合肽的本发明免疫原性文库以这种方式体现，即具有免疫原性，可启动与多种AIDS-基因型的gp120变异体相互作用的抗体的产生1并具有结合早期抗体与AIDS-1的能力。文库的结构组成在其描述中公开。借助于与健康人的血清和血清比较的AIDS-1感染者血清的免疫测定分析的间接变体，研究了嵌合肽的免疫文库结合针对AIDS-1的特异性抗体的能力。标准的AIDS-1面板。通过嵌合肽文库对实验动物进行免疫可产生与多种人类免疫缺陷基因型的gp 120变异体相互作用的特异性抗体。

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公开/公告号WO2004031226A1

专利类型
公开/公告日2004-04-15

原文格式PDF
申请/专利权人 GOSUDARSTVENNY NAUCHNY TSENTR VIRUSOLOGII BIOTEKHNOLOGII VEKTOR;MAKSYUTOV AMIR ZAKIEVICH;KOLOBOV ALEKSANDR ALEKSANDROVICH;RYZHIKOV ALEKSANDR BORISOVICH;KANEV ALEKSANDR NIKOLAEVICH;MAKSYUTOV ZAKI AMIROVICH;
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申请/专利号WO2003RU00423
发明设计人 MAKSYUTOV AMIR ZAKIEVICH;KOLOBOV ALEKSANDR ALEKSANDROVICH;RYZHIKOV ALEKSANDR BORISOVICH;KANEV ALEKSANDR NIKOLAEVICH;MAKSYUTOV ZAKI AMIROVICH;
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申请日2003-09-29
分类号C07K14/155;A61K39/21;A61P31/18;
国家 WO
入库时间 2022-08-21 22:57:13

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