首页> 外国专利> A ROLE FOR SURVIVIN IN APOPTOSIS OF MYELOID CELLS

A ROLE FOR SURVIVIN IN APOPTOSIS OF MYELOID CELLS

机译:Survivin在髓样细胞凋亡中的作用

摘要

The invention provides a method for detecting apoptosis in a myeloid cell comprising detecting an alteration in any one of: i) a Survivin polypeptide having an amino acid sequence as set out in SEQ ID NO: 1; ii) a polypeptide having at least 80 % homology with i); iii) a nucleic acid encoding a polypeptide having the sequence set out in i) or ii); iv) a nucleic acid which hybridises under stringent conditions to the sequence set out in iii); or v) the complement of iii) or iv). The invention accordingly provides a method of modulating apoptosis in neutrophils by modulating Survivin gene expression and a method of treating inflammatory disease by modulating Survivin gene expression of function.
机译:本发明提供了一种检测髓样细胞凋亡的方法,该方法包括检测以下任一者的改变:i)具有SEQ ID NO:1所示氨基酸序列的Survivin多肽。 ii)与i)具有至少80%同源性的多肽; iii)编码具有i)或ii)中列出的序列的多肽的核酸; iv)在严格条件下与iii)中列出的序列杂交的核酸;或v)iii)或iv)的补充。因此,本发明提供了通过调节Survivin基因表达来调节中性粒细胞凋亡的方法,以及通过调节Survivin基因的功能表达来治疗炎性疾病的方法。

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