首页> 外国专利> THE USE OF SPECIFIED TCF TARGET GENES TO IDENTIFY DRUGS FOR THE TREATMENT OF CANCER, IN PARTICULAR COLORECTAL CANCER, IN WHICH TCF/Beta-CATENIN/WNT SIGNALLING PLAYS A CENTRAL ROLE

THE USE OF SPECIFIED TCF TARGET GENES TO IDENTIFY DRUGS FOR THE TREATMENT OF CANCER, IN PARTICULAR COLORECTAL CANCER, IN WHICH TCF/Beta-CATENIN/WNT SIGNALLING PLAYS A CENTRAL ROLE

机译：在TCF /β-catenin/ WNT信号标记中发挥重要作用的是，使用特定的TCF目标基因识别药物以治疗特别是大肠癌的癌症

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摘要

The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/ beta -catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/ beta -catenin signaling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.

机译：本发明涉及TCF靶基因表达蛋白的抑制剂的用途，该抑制剂的表达受TCF /β-连环蛋白复合物调节，用于制备治疗TCF /β-连环蛋白信号转导失调的癌症的治疗组合物。。这样的抑制剂可以是用于RNAi的抗体，小分子，反义RNA和dsRNA。本发明还涉及这些抑制剂本身。

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公开/公告号AU2003253046A1

专利类型
公开/公告日2004-01-23

原文格式PDF
申请/专利权人 KIADIS PHARMA B.V.;
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申请/专利号AU20030253046
发明设计人 FREDERIC COLLAND;NICHOLAS BARKER;JOHANNES CAROLUS CLEVERS;EDUARD GOMEZ;MARCUS LAMBERTUS VAN DE WETERING;ELENA SANCHO SUILS;
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申请日2003-07-08
分类号A61K31;A61K38/18;A61K39;A61K48;A61P35;C07K16/30;C12N15/11;C12Q1/68;G01N33/574;
国家 AU
入库时间 2022-08-21 23:02:57

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