首页> 外国专利> METHOD FOR CANCER DETECTION, PROGRESSION ANALYSIS AND MALIGNTUMOUR PROGNOSIS BASED ON THE STUDY OF METABOLIC MARKERS OF THE CELL

METHOD FOR CANCER DETECTION, PROGRESSION ANALYSIS AND MALIGNTUMOUR PROGNOSIS BASED ON THE STUDY OF METABOLIC MARKERS OF THE CELL

机译:基于细胞代谢标志物研究的癌症检测,进展分析和恶性肿瘤预测方法

摘要

The invention relates to a method for cancer detection, progression analysis and malign tumour prognosis based on the study of metabolic markers of the cell. The inventive method consists in using the study of the protein expression of the bioenergetic function of the mitochondrion, such as the .beta.-catalytic subunit of the H+-ATP synthase, in relation to structural proteins and mitochondrial respiration, such as hsp 60 and cytochrome oxidas e subunits I and IV respectively, and said mitochondrial bioenergetic index, (ratio of .beta.-ATPasa/hsp60; .beta.-ATPasa/COX I; .beta.-ATPasa/COX IV) which relates to the cellular protein expression of the glycolytic pathway, such as glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase M, in order to generate the bioenergetic index of the cell.
机译:基于细胞代谢标记物的研究,本发明涉及一种用于癌症检测,进展分析和恶性肿瘤预后的方法。本发明的方法在于利用线粒体的生物能功能的蛋白质表达的研究,例如H + -ATP合酶的β-催化亚基,与结构蛋白和线粒体呼吸(例如hsp 60和hsp)有关。细胞色素氧化亚基I和IV,以及与细胞蛋白有关的所述线粒体生物能指数(β-ATPasa/ hsp60的比率;β-ATPasa/ COX I;β-ATPasa/ COX IV)糖酵解途径的表达,例如3-磷酸甘油醛脱氢酶和丙酮酸激酶M,以产生细胞的生物能指数。

著录项

  • 公开/公告号CA2487176A1

    专利类型

  • 公开/公告日2003-12-04

    原文格式PDF

  • 申请/专利权人 UNIVERSIDAD AUTONOMA DE MADRID;

    申请/专利号CA20032487176

  • 发明设计人 CUEZVA MARCOS JOSE MANUEL;

    申请日2003-05-20

  • 分类号G01N33/574;C07K14/47;

  • 国家 CA

  • 入库时间 2022-08-21 23:04:30

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