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2-ARACHIDONYLGLYCEROL, AN INHIBITOR OF THE TUMOR NECROSE FACTOR -ALFA AND NEUROPROTECTOR OF THE BRAIN IN CLOSED HEAD INJURIES
2-ARACHIDONYLGLYCEROL, AN INHIBITOR OF THE TUMOR NECROSE FACTOR -ALFA AND NEUROPROTECTOR OF THE BRAIN IN CLOSED HEAD INJURIES
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机译:2-花生四烯酸甘油酯,一种封闭性颅脑损伤的肿瘤坏死因子-α的抑制剂和脑神经保护因子
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摘要
The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF-alpha), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF-alpha and/or by radical oxygen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG. It comprises also the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications.
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