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IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES USING CELLS THAT PRESENT ANTIGENS SENSITIZED WITH PROTEIN COMPLEXES OF THERMAL-ANTIGENIC SHOCK
IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES USING CELLS THAT PRESENT ANTIGENS SENSITIZED WITH PROTEIN COMPLEXES OF THERMAL-ANTIGENIC SHOCK
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机译:使用目前用热抗原性休克蛋白复合物敏感的抗原的细胞对癌症和感染性疾病进行免疫治疗
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摘要
The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic diseases based on the administration of macrophages and/or other antigen presenting cells (APC) sensitized with heat shock proteins non-covalently bound to peptide complexes and/or antigenic components. APC are incubated in the presence of hsp-peptide complexes and/or antigenic components in vitro. The sensitized cells are reinfused into the patient with or without treatment with cytokines including but not limited to interferon- alpha , interferon- alpha , interleukin-2, interleukin-4, interleukin-6 and tumor neurosis factor.
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