首页> 外国专利> IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES USING CELLS THAT PRESENT ANTIGENS SENSITIZED WITH PROTEIN COMPLEXES OF THERMAL-ANTIGENIC SHOCK

IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES USING CELLS THAT PRESENT ANTIGENS SENSITIZED WITH PROTEIN COMPLEXES OF THERMAL-ANTIGENIC SHOCK

机译:使用目前用热抗原性休克蛋白复合物敏感的抗原的细胞对癌症和感染性疾病进行免疫治疗

摘要

The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic diseases based on the administration of macrophages and/or other antigen presenting cells (APC) sensitized with heat shock proteins non-covalently bound to peptide complexes and/or antigenic components. APC are incubated in the presence of hsp-peptide complexes and/or antigenic components in vitro. The sensitized cells are reinfused into the patient with or without treatment with cytokines including but not limited to interferon- alpha , interferon- alpha , interleukin-2, interleukin-4, interleukin-6 and tumor neurosis factor.
机译:本发明涉及基于巨噬细胞和/或其他非热激蛋白敏化的抗原呈递细胞(APC)的给药,用于增强免疫应答以及预防和治疗感染性疾病或原发性和转移性肿瘤性疾病的方法和组合物。共价结合至肽复合物和/或抗原成分。在体外,在hsp-肽复合物和/或抗原成分存在的情况下孵育APC。将经过敏化的细胞重新注入患者体内,无论是否接受细胞因子治疗,细胞因子包括但不限于干扰素-α,干扰素-α,白介素-2,白介素-4,白介素-6和肿瘤神经症因子。

著录项

  • 公开/公告号PT857068E

    专利类型

  • 公开/公告日2004-09-30

    原文格式PDF

  • 申请/专利权人 UNIV FORDHAM;

    申请/专利号PT19960930819T

  • 发明设计人 SRIVASTAVA PRAMOD K;

    申请日1996-09-11

  • 分类号C12N5/06;A61K39/00;A61K38/19;A61P31/00;A61P35/00;A61P37/00;

  • 国家 PT

  • 入库时间 2022-08-21 23:08:51

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