首页> 外国专利> 6H-OXAZOLO-4,5-EINDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

6H-OXAZOLO-4,5-EINDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

机译:6H-恶唑啉[-4,5-E]吲哚衍生物为烟碱型乙酰胆碱受体配体和/或5-羟色胺配体,其制备方法和含有它们的药物组合物

摘要

Compounds of the formula I in which RSUP1/SUP, RSUP2/SUP, RSUP3 /SUPand RSUP4 /SUPare as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychoses, schizophrenia, depression, anxiety states, dementia, in particular Alzheimer's disease and Lewy bodies dementia, neurodegenerative disorders, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, Tourette's syndrome, learning and memory restrictions, bulimia anorexia nervosa or other eating disorders, compulsvie behaviour, premenstrual syndrome, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds, and for the treatment of disorders which are characterised by an excess of circulating serotonin or by serotonergic hyperactivity.
机译:其中R 1 ,R 2 ,R 3 和R 4 的式I化合物的定义如下权利要求1的化合物,其是烟碱乙酰胆碱受体的配体和/或5-羟色胺能配体,并且适合于预防或治疗精神病,精神分裂症,抑郁症,焦虑症,痴呆症,特别是阿尔茨海默氏病和路易体痴呆症,神经退行性疾病,帕金森氏病,肌萎缩性侧索硬化症,亨廷顿氏病,图雷特氏综合症,学习和记忆障碍,神经性贪食症厌食症或其他饮食失调,强迫行为,经前综合症,年龄诱发的记忆障碍,尼古丁依赖戒断症状的缓解,中风或有毒化合物对大脑的损害,以及用于治疗以循环血清素过多或血清素能亢进为特征的疾病。

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