首页> 外国专利> Pharmaceutically acceptable compound or salt thereof, pharmaceutical composition, packaged pharmaceutical preparation, methods for modulating mch binding to an mch receptor and mvc, to alter the signal transduction activity of an mch receptor in a cell, to treat a disease or disorder associated with pathogenic obesity mch receptor activation and to determine the presence or absence of mch receptor in a sample, and use of a compound

Pharmaceutically acceptable compound or salt thereof, pharmaceutical composition, packaged pharmaceutical preparation, methods for modulating mch binding to an mch receptor and mvc, to alter the signal transduction activity of an mch receptor in a cell, to treat a disease or disorder associated with pathogenic obesity mch receptor activation and to determine the presence or absence of mch receptor in a sample, and use of a compound

机译:药学上可接受的化合物或其盐,药物组合物,包装的药物制剂,调节mch与mch受体和mvc结合,改变mch受体在细胞中的信号转导活性,治疗与致病性肥胖症相关的疾病或病症的方法mch受体激活并确定样品中mch受体的存在与否以及化合物的用途

摘要

"PHARMACEUTICALLY ACCEPTABLE COMPOUND OR SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, PACKED PHARMACEUTICAL PREPARATION, METHODS FOR MODULATING MCH CONNECTION TO A MCH AND MVC RECEIVER, FOR ALTERING THE TRANSDUCT C TRANSDUCT ACTIVITY A DISEASE OR DISORDER ASSOCIATED WITH PATHOGENIC MCH RECEIVER ACTIVATION AND OBESITY AND TO DETERMINE THE PRESENCE OR ABSENCE OF MCH RECEIVER IN A SAMPLE AND USE OF A COMPOUND. " Melanin-concentrating hormone receptor ligands (especially 1-benzyl-4-aryl piperazine, 1-benzyl-4-aryl piperidine and related compounds) capable of modulating MCH receptor activity are provided. Such ligands may be used to modulate the binding of MCH to MCH receptors in vivo or in vitro and are particularly useful in treating a variety of metabolic, eating and sexual disorders in humans, domesticated pets and farm animals. Pharmaceutical compositions and methods are provided for treating such disorders, as are methods for using such ligands to detect MCH receptors (e.g., receptor localization studies).
机译:“相同的药物可接受的化合物或盐,药物成分,包装的药物制剂,调节MCH与MCH和MVC接收器的连接的方法,以改变疾病或与之相关的疾病和疾病的转移C传导活性确定样品中MCH受体的存在或不存在以及化合物的使用。黑色素浓缩激素受体配体(特别是1-苄基-4-芳基哌嗪,1-苄基-4-芳基哌啶和相关化合物)能够调节提供了MCH受体活性。这样的配体可用于体内或体外调节MCH与MCH受体的结合,并且特别用于治疗人,家养宠物和农场动物的各种代谢,饮食和性疾病。提供了用于治疗此类疾病的药物组合物和方法,以及使用此类配体检测MCH受体的方法(例如,受体定位研究)。

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