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Method for releasing in vivo a chimeric oligonucleotide into target cells of a human or animal tissue, to treat a disease, to obtain an animal model, to select cosmetic or pharmaceutical compounds, to treat a human host having retinopathy and to treat a host human or animal having ocular neovascularization, chimeric alligonucleotide, pharmaceutical composition, animal model, and use thereof
Method for releasing in vivo a chimeric oligonucleotide into target cells of a human or animal tissue, to treat a disease, to obtain an animal model, to select cosmetic or pharmaceutical compounds, to treat a human host having retinopathy and to treat a host human or animal having ocular neovascularization, chimeric alligonucleotide, pharmaceutical composition, animal model, and use thereof
"METHODS TO RELEASE A CHEMICAL OLIGONUCLEOTIDE INSIDE TARGET CELLS OF A HUMAN OR ANIMAL TISSUE, TO TREAT A DISEASE, TO OBTAIN AN ANIMAL MODEL, TO SELECT COSMETIC COMPOUNDS AND A POST HETARIAN PHARMACEUTICAL COMPOUNDS HUMAN OR ANIMAL HOSTING WITH OCCULAR NEOVASCULARIZATION, CHEMICAL OLIGONUCLEOTIDE, PHARMACEUTICAL COMPOSITION, ANIMAL MODEL, AND, USE OF THE SAME ". The present invention provides a method for enhancing the in vivo release of chimeric oligonucleotides, for example containing DNA / 2α OMeRNA, into cells of a plant, animal, or human, comprising a step of topically applying to or injecting into a tissue, or tissue adjacent to a tissue, containing said cells, a composition comprising said chimeric oligonucleotide, then preceded by or simultaneous with a step of iontophoresis said chimeric oligonucleotide into said cells, and refers to a method of gene therapy comprising iontophoresis transfer of a chimeric DNA / 2? OMeRNA oligonucleotide. The present invention also relates to particular chimeric DNA / 2? OMeRNA oligonucleotides capable of inducing or inhibiting the expression of a specific gene involved in ocular function by inducing or retaining a mutation in that specific gene, and its use as a therapeutic composition for prevent or treat eye diseases.
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